Essays Biochemistry Volume 42

Essays Biochemistry Volume 42-10
Essay Review: Hustlers and Patrons of Science, Millikan's School: A History of the California Institute of Technology, Partners in Science: Foundations and Natural Scientists 1900–1945. Find out more about the Kindle Personal Document Service.

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This penetrating case study of institution building and entrepreneurship in science shows how a minor medical speciality evolved into a large and powerful academic discipline.

OBJECTIVE Activation of polyamine metabolism is closely associated with cellular proliferation.

Correlation of regional biochemical and histomorphological data in rapidly growing neoplasms showed high enzyme activity in solid tumour parts and low activity in necrotic areas.

CONCLUSIONS Novel data relating ODC activation and polyamine concentrations to neuropathology is presented indicating that high ODC activity represents a biochemical marker of malignancy in brain tumours.

The author's view of the political economy of modern science will be of interest to historians and social scientists, scientific and medical practitioners, and anyone interested in the ecology of knowledge in scientific institutions and professions.

Science is shaped by its service roles in particular local contexts: This is the central theme.Only one patient with a primary glioblastoma multiforme and patients with recurrent gliomas had received chemotherapy, radiotherapy, or both before tumour removal.During neurosurgery up to five samples from intracranial neoplasms were obtained and, immediately after excision, frozen in liquid nitrogen and stored at −80°C until analysis.Pathways of polyamine metabolism and interconversion. ODC=Ornithine decarboxylase; SAMDC=S-adenosylmethionine decarboxylase; dec S-adenosylmethionine=decarboxylated S-adenosylmethionine; SAT=spermidine/spermine NIn recent studies of experimental gliomas, we showed that ODC activity represents a reliable biochemical marker of neoplastic growth in the brain.20 21 These data were obtained from highly malignant anaplastic gliomas.In human brain tumours, individual tumour behaviour does not always correspond to the histologically defined neuropathology. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site.Detailed information on how Wiley uses cookies can be found in our Privacy Policy. The book shows how biochemistry was defined as a distinct discipline by the programmatic vision of individual biochemists and of patrons and competitors in related disciplines. Drawing extensively on little-used archival sources, the author analyses in detail how biomedical science became a central part of medical training and practice. The author argues that the priorities and styles of various departments and schools of biochemistry reflect systematic social relationships between that discipline and biology, chemistry and medicine. Chronicle of His Life and Accomplishments in Immunology, Cancer Research, and Chemotherapy1: Paul Ehrlich's Recipe for Success: “Patience, Ability, Money and Luck”. It shows how discipline builders used research programmes as strategies that they adapted to the opportunities offered by changing educational markets and national medical reform movements in the United States, Britain and Germany.


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